<span style="font-size:14px"><span style="font-family:Arial,Helvetica,sans-serif">The genus Piper<em> </em>belongs to family piperaceae which has over 700 species distributed in both hemispheres. The piperaceae family is a source of many biologically active photochemical with tremendous potential for medicinal uses. A wide range of secondary metabolites mainly alkaloids, amides and terpenes are reported from the various species of piper which are of great economical and medicinal importance. This paper reports the isolation of various sesqueterpenes such as &delta;&ndash;elemene, &delta;&ndash;cadinene, &alpha;&ndash;copane, caryophyllene, &alpha;&ndash;caryophyllene, &beta;&ndash;bisabolene, and methyl benzene from the oil of the hot petroleum ether extract of <em>Piper nigrum </em>seeds. These phytochemicals are analysed by GC-MS spectral analysis.</span></span>